diff --git a/src/Symfony/Component/Mailer/Bridge/Mailgun/Http/Api/MailgunTransport.php b/src/Symfony/Component/Mailer/Bridge/Mailgun/Http/Api/MailgunTransport.php
index dc047c2e87..9e61ee4dcd 100644
--- a/src/Symfony/Component/Mailer/Bridge/Mailgun/Http/Api/MailgunTransport.php
+++ b/src/Symfony/Component/Mailer/Bridge/Mailgun/Http/Api/MailgunTransport.php
@@ -27,15 +27,17 @@ use Symfony\Contracts\HttpClient\HttpClientInterface;
  */
 class MailgunTransport extends AbstractApiTransport
 {
-    private const ENDPOINT = 'https://api.mailgun.net/v3/%domain%/messages';
+    private const ENDPOINT = 'https://api.%region_dot%mailgun.net/v3/%domain%/messages';
 
     private $key;
     private $domain;
+    private $region;
 
-    public function __construct(string $key, string $domain, HttpClientInterface $client = null, EventDispatcherInterface $dispatcher = null, LoggerInterface $logger = null)
+    public function __construct(string $key, string $domain, string $region = null, HttpClientInterface $client = null, EventDispatcherInterface $dispatcher = null, LoggerInterface $logger = null)
     {
         $this->key = $key;
         $this->domain = $domain;
+        $this->region = $region;
 
         parent::__construct($client, $dispatcher, $logger);
     }
@@ -48,7 +50,7 @@ class MailgunTransport extends AbstractApiTransport
             $headers[] = $header->toString();
         }
 
-        $endpoint = str_replace('%domain%', urlencode($this->domain), self::ENDPOINT);
+        $endpoint = str_replace(['%domain%', '%region_dot%'], [urlencode($this->domain), 'us' !== ($this->region ?: 'us') ? $this->region.'.' : ''], self::ENDPOINT);
         $response = $this->client->request('POST', $endpoint, [
             'auth_basic' => 'api:'.$this->key,
             'headers' => $headers,
diff --git a/src/Symfony/Component/Mailer/Bridge/Mailgun/Http/MailgunTransport.php b/src/Symfony/Component/Mailer/Bridge/Mailgun/Http/MailgunTransport.php
index 2d3fe15a08..913ed705d9 100644
--- a/src/Symfony/Component/Mailer/Bridge/Mailgun/Http/MailgunTransport.php
+++ b/src/Symfony/Component/Mailer/Bridge/Mailgun/Http/MailgunTransport.php
@@ -27,14 +27,16 @@ use Symfony\Contracts\HttpClient\HttpClientInterface;
  */
 class MailgunTransport extends AbstractHttpTransport
 {
-    private const ENDPOINT = 'https://api.mailgun.net/v3/%domain%/messages.mime';
+    private const ENDPOINT = 'https://api.%region_dot%mailgun.net/v3/%domain%/messages.mime';
     private $key;
     private $domain;
+    private $region;
 
-    public function __construct(string $key, string $domain, HttpClientInterface $client = null, EventDispatcherInterface $dispatcher = null, LoggerInterface $logger = null)
+    public function __construct(string $key, string $domain, string $region = null, HttpClientInterface $client = null, EventDispatcherInterface $dispatcher = null, LoggerInterface $logger = null)
     {
         $this->key = $key;
         $this->domain = $domain;
+        $this->region = $region;
 
         parent::__construct($client, $dispatcher, $logger);
     }
@@ -49,7 +51,7 @@ class MailgunTransport extends AbstractHttpTransport
         foreach ($body->getPreparedHeaders()->getAll() as $header) {
             $headers[] = $header->toString();
         }
-        $endpoint = str_replace('%domain%', urlencode($this->domain), self::ENDPOINT);
+        $endpoint = str_replace(['%domain%', '%region_dot%'], [urlencode($this->domain), 'us' !== ($this->region ?: 'us') ? $this->region.'.' : ''], self::ENDPOINT);
         $response = $this->client->request('POST', $endpoint, [
             'auth_basic' => 'api:'.$this->key,
             'headers' => $headers,
diff --git a/src/Symfony/Component/Mailer/Bridge/Mailgun/Smtp/MailgunTransport.php b/src/Symfony/Component/Mailer/Bridge/Mailgun/Smtp/MailgunTransport.php
index 105ab46ecd..c288a46bdd 100644
--- a/src/Symfony/Component/Mailer/Bridge/Mailgun/Smtp/MailgunTransport.php
+++ b/src/Symfony/Component/Mailer/Bridge/Mailgun/Smtp/MailgunTransport.php
@@ -22,9 +22,9 @@ use Symfony\Component\Mailer\Transport\Smtp\EsmtpTransport;
  */
 class MailgunTransport extends EsmtpTransport
 {
-    public function __construct(string $username, string $password, EventDispatcherInterface $dispatcher = null, LoggerInterface $logger = null)
+    public function __construct(string $username, string $password, string $region = null, EventDispatcherInterface $dispatcher = null, LoggerInterface $logger = null)
     {
-        parent::__construct('smtp.mailgun.org', 465, 'ssl', null, $dispatcher, $logger);
+        parent::__construct('us' !== ($region ?: 'us') ? sprintf('smtp.%s.mailgun.org', $region) : 'smtp.mailgun.org', 465, 'ssl', null, $dispatcher, $logger);
 
         $this->setUsername($username);
         $this->setPassword($password);
diff --git a/src/Symfony/Component/Mailer/Tests/TransportTest.php b/src/Symfony/Component/Mailer/Tests/TransportTest.php
index 0d1f143262..a12aae4830 100644
--- a/src/Symfony/Component/Mailer/Tests/TransportTest.php
+++ b/src/Symfony/Component/Mailer/Tests/TransportTest.php
@@ -23,7 +23,9 @@ use Symfony\Component\Mailer\Bridge\Sendgrid;
 use Symfony\Component\Mailer\Exception\InvalidArgumentException;
 use Symfony\Component\Mailer\Exception\LogicException;
 use Symfony\Component\Mailer\Transport;
+use Symfony\Component\Mime\Email;
 use Symfony\Contracts\HttpClient\HttpClientInterface;
+use Symfony\Contracts\HttpClient\ResponseInterface;
 
 class TransportTest extends TestCase
 {
@@ -106,6 +108,15 @@ class TransportTest extends TestCase
         $this->assertEquals('pa$s', $transport->getPassword());
         $this->assertProperties($transport, $dispatcher, $logger);
 
+        $transport = Transport::fromDsn('smtp://'.urlencode('u$er').':'.urlencode('pa$s').'@mailgun', $dispatcher, null, $logger);
+        $this->assertEquals('smtp.mailgun.org', $transport->getStream()->getHost());
+
+        $transport = Transport::fromDsn('smtp://'.urlencode('u$er').':'.urlencode('pa$s').'@mailgun?region=eu', $dispatcher, null, $logger);
+        $this->assertEquals('smtp.eu.mailgun.org', $transport->getStream()->getHost());
+
+        $transport = Transport::fromDsn('smtp://'.urlencode('u$er').':'.urlencode('pa$s').'@mailgun?region=us', $dispatcher, null, $logger);
+        $this->assertEquals('smtp.mailgun.org', $transport->getStream()->getHost());
+
         $client = $this->createMock(HttpClientInterface::class);
         $transport = Transport::fromDsn('http://'.urlencode('u$er').':'.urlencode('pa$s').'@mailgun', $dispatcher, $client, $logger);
         $this->assertInstanceOf(Mailgun\Http\MailgunTransport::class, $transport);
@@ -115,6 +126,25 @@ class TransportTest extends TestCase
             'client' => $client,
         ]);
 
+        $response = $this->createMock(ResponseInterface::class);
+        $response->expects($this->any())->method('getStatusCode')->willReturn(200);
+        $message = (new Email())->from('me@me.com')->to('you@you.com')->subject('hello')->text('Hello you');
+
+        $client = $this->createMock(HttpClientInterface::class);
+        $client->expects($this->once())->method('request')->with('POST', 'https://api.mailgun.net/v3/pa%24s/messages.mime')->willReturn($response);
+        $transport = Transport::fromDsn('http://'.urlencode('u$er').':'.urlencode('pa$s').'@mailgun', $dispatcher, $client, $logger);
+        $transport->send($message);
+
+        $client = $this->createMock(HttpClientInterface::class);
+        $client->expects($this->once())->method('request')->with('POST', 'https://api.eu.mailgun.net/v3/pa%24s/messages.mime')->willReturn($response);
+        $transport = Transport::fromDsn('http://'.urlencode('u$er').':'.urlencode('pa$s').'@mailgun?region=eu', $dispatcher, $client, $logger);
+        $transport->send($message);
+
+        $client = $this->createMock(HttpClientInterface::class);
+        $client->expects($this->once())->method('request')->with('POST', 'https://api.mailgun.net/v3/pa%24s/messages.mime')->willReturn($response);
+        $transport = Transport::fromDsn('http://'.urlencode('u$er').':'.urlencode('pa$s').'@mailgun?region=us', $dispatcher, $client, $logger);
+        $transport->send($message);
+
         $transport = Transport::fromDsn('api://'.urlencode('u$er').':'.urlencode('pa$s').'@mailgun', $dispatcher, $client, $logger);
         $this->assertInstanceOf(Mailgun\Http\Api\MailgunTransport::class, $transport);
         $this->assertProperties($transport, $dispatcher, $logger, [
@@ -123,6 +153,21 @@ class TransportTest extends TestCase
             'client' => $client,
         ]);
 
+        $client = $this->createMock(HttpClientInterface::class);
+        $client->expects($this->once())->method('request')->with('POST', 'https://api.mailgun.net/v3/pa%24s/messages')->willReturn($response);
+        $transport = Transport::fromDsn('api://'.urlencode('u$er').':'.urlencode('pa$s').'@mailgun', $dispatcher, $client, $logger);
+        $transport->send($message);
+
+        $client = $this->createMock(HttpClientInterface::class);
+        $client->expects($this->once())->method('request')->with('POST', 'https://api.eu.mailgun.net/v3/pa%24s/messages')->willReturn($response);
+        $transport = Transport::fromDsn('api://'.urlencode('u$er').':'.urlencode('pa$s').'@mailgun?region=eu', $dispatcher, $client, $logger);
+        $transport->send($message);
+
+        $client = $this->createMock(HttpClientInterface::class);
+        $client->expects($this->once())->method('request')->with('POST', 'https://api.mailgun.net/v3/pa%24s/messages')->willReturn($response);
+        $transport = Transport::fromDsn('api://'.urlencode('u$er').':'.urlencode('pa$s').'@mailgun?region=us', $dispatcher, $client, $logger);
+        $transport->send($message);
+
         $this->expectException(LogicException::class);
         Transport::fromDsn('foo://mailgun');
     }
diff --git a/src/Symfony/Component/Mailer/Transport.php b/src/Symfony/Component/Mailer/Transport.php
index 326452ede9..ad5ea86462 100644
--- a/src/Symfony/Component/Mailer/Transport.php
+++ b/src/Symfony/Component/Mailer/Transport.php
@@ -101,13 +101,13 @@ class Transport
                 }
 
                 if ('smtp' === $parsedDsn['scheme']) {
-                    return new Mailgun\Smtp\MailgunTransport($user, $pass, $dispatcher, $logger);
+                    return new Mailgun\Smtp\MailgunTransport($user, $pass, $query['region'] ?? null, $dispatcher, $logger);
                 }
                 if ('http' === $parsedDsn['scheme']) {
-                    return new Mailgun\Http\MailgunTransport($user, $pass, $client, $dispatcher, $logger);
+                    return new Mailgun\Http\MailgunTransport($user, $pass, $query['region'] ?? null, $client, $dispatcher, $logger);
                 }
                 if ('api' === $parsedDsn['scheme']) {
-                    return new Mailgun\Http\Api\MailgunTransport($user, $pass, $client, $dispatcher, $logger);
+                    return new Mailgun\Http\Api\MailgunTransport($user, $pass, $query['region'] ?? null, $client, $dispatcher, $logger);
                 }
 
                 throw new LogicException(sprintf('The "%s" scheme is not supported for mailer "%s".', $parsedDsn['scheme'], $parsedDsn['host']));
diff --git a/src/Symfony/Component/Mailer/composer.json b/src/Symfony/Component/Mailer/composer.json
index b9852124f1..91bfb1031d 100644
--- a/src/Symfony/Component/Mailer/composer.json
+++ b/src/Symfony/Component/Mailer/composer.json
@@ -26,7 +26,7 @@
         "symfony/amazon-mailer": "^4.3",
         "symfony/google-mailer": "^4.3",
         "symfony/http-client-contracts": "^1.1",
-        "symfony/mailgun-mailer": "^4.3",
+        "symfony/mailgun-mailer": "^4.3.2",
         "symfony/mailchimp-mailer": "^4.3",
         "symfony/postmark-mailer": "^4.3",
         "symfony/sendgrid-mailer": "^4.3"